Annexin A3 (ANXA3)

About Annexin A3

Annexin A3 (ANXA3) is a protein from Homo sapiens identified by UniProt accession P12429, 323 residues long. MolForge cross-references it against 0 known binders and 256 disease associations.

Target properties

Protein name	Annexin A3
UniProt accession	P12429
Gene	ANXA3
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (256)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.41
monocyte count · score 0.39
rheumatoid arthritis · score 0.34
serum albumin measurement · score 0.31
aspartate aminotransferase measurement · score 0.31
total blood protein measurement · score 0.31
serum gamma-glutamyl transferase measurement · score 0.29
daytime rest measurement · score 0.28
myeloid white cell count · score 0.27
mean corpuscular volume · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12429-F1	alphafold	PREDICTED	96.20	—

Amino-acid sequence (323 residues)

MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN AQRQLIVKEY QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK KSMKGAGTNE DALIEILTTR TSRQMKDISQ AYYTVYKKSL GDDISSETSG DFRKALLTLA DGRRDESLKV DEHLAKQDAQ ILYKAGENRW GTDEDKFTEI LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL LAIVNCVRNT PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY SAIKSDTSGD YEITLLKICG GDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards