Creatine kinase U-type, mitochondrial (CKMT1A)

About Creatine kinase U-type, mitochondrial

Creatine kinase U-type, mitochondrial (CKMT1A) is a protein from Homo sapiens identified by UniProt accession P12532, 417 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Creatine kinase U-type, mitochondrial
UniProt accession	P12532
Gene	CKMT1A
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
Parkinson disease · score 0.31
multiple sclerosis · score 0.31
Alzheimer disease · score 0.31
lysosomal storage disease · score 0.31
neuroinflammatory disorder · score 0.24
neoplasm · score 0.07
cancer · score 0.07
mean corpuscular hemoglobin concentration · score 0.05
lymphocyte count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12532-F1	alphafold	PREDICTED	89.29	—

Amino-acid sequence (417 residues)

MAGPFSRLLS ARPGLRLLAL AGAGSLAAGF LLRPEPVRAA SERRRLYPPS AEYPDLRKHN NCMASHLTPA VYARLCDKTT PTGWTLDQCI QTGVDNPGHP FIKTVGMVAG DEETYEVFAD LFDPVIQERH NGYDPRTMKH TTDLDASKIR SGYFDERYVL SSRVRTGRSI RGLSLPPACT RAERREVERV VVDALSGLKG DLAGRYYRLS EMTEAEQQQL IDDHFLFDKP VSPLLTAAGM ARDWPDARGI WHNNEKSFLI WVNEEDHTRV ISMEKGGNMK RVFERFCRGL KEVERLIQER GWEFMWNERL GYILTCPSNL GTGLRAGVHI KLPLLSKDSR FPKILENLRL QKRGTGGVDT AATGGVFDIS NLDRLGKSEV ELVQLVIDGV NYLIDCERRL ERGQDIRIPT PVIHTKH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards