About Granzyme A
Granzyme A (GZMA) is a protein
from Homo sapiens identified by UniProt accession
P12544, 262 residues long.
MolForge cross-references it against 0 known binders and
285 disease associations.
Target properties
| Protein name | Granzyme A |
|---|
| UniProt accession | P12544 |
|---|
| Gene | GZMA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 262 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (285)
Diseases linked to this target (Open Targets).
- Sepsis · score 0.09
- neoplasm · score 0.08
- rheumatoid arthritis · score 0.06
- lean body mass · score 0.06
- hepatocellular carcinoma · score 0.05
- Chronic mucocutaneous candidosis · score 0.05
- blood protein measurement · score 0.05
- graft versus host disease · score 0.05
- fat body mass · score 0.05
- infection · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12544-F1 | alphafold | PREDICTED | 91.64 | — |
Amino-acid sequence (262 residues)
MRNSYRFLAS SLSVVVSLLL IPEDVCEKII GGNEVTPHSR PYMVLLSLDR KTICAGALIA KDWVLTAAHC NLNKRSQVIL GAHSITREEP TKQIMLVKKE FPYPCYDPAT REGDLKLLQL MEKAKINKYV TILHLPKKGD DVKPGTMCQV AGWGRTHNSA SWSDTLREVN ITIIDRKVCN DRNHYNFNPV IGMNMVCAGS LRGGRDSCNG DSGSPLLCEG VFRGVTSFGL ENKCGDPRGP GVYILLSKKH LNWIIMTIKG AV
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