Bone morphogenetic protein 2 (BMP2)

About Bone morphogenetic protein 2

Bone morphogenetic protein 2 (BMP2) is a protein from Homo sapiens identified by UniProt accession P12643, 396 residues long. MolForge cross-references it against 0 known binders and 664 disease associations.

Target properties

Protein name	Bone morphogenetic protein 2
UniProt accession	P12643
Gene	BMP2
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (664)

Diseases linked to this target (Open Targets).

brachydactyly type A2 · score 0.67
short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1 · score 0.65
short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies · score 0.63
colorectal cancer · score 0.50
heel bone mineral density · score 0.50
refractive error · score 0.46
bone quantitative ultrasound measurement · score 0.45
sitting height measurement · score 0.44
colorectal adenoma · score 0.44
neurodegenerative disease · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12643-F1	alphafold	PREDICTED	79.59	—

Amino-acid sequence (396 residues)

MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL SEFELRLLSM FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE RAASRANTVR SFHHEESLEE LPETSGKTTR RFFFNLSSIP TEEFITSAEL QVFREQMQDA LGNNSSFHHR INIYEIIKPA TANSKFPVTR LLDTRLVNQN ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS KRHVRISRSL HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN SVNSKIPKAC CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards