Bone morphogenetic protein 4 (BMP4)

About Bone morphogenetic protein 4

Bone morphogenetic protein 4 (BMP4) is a protein from Homo sapiens identified by UniProt accession P12644, 408 residues long. MolForge cross-references it against 0 known binders and 1,049 disease associations.

Target properties

Protein name	Bone morphogenetic protein 4
UniProt accession	P12644
Gene	BMP4
Organism	Homo sapiens
Length	408 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1049)

Diseases linked to this target (Open Targets).

microphthalmia with brain and digit anomalies · score 0.79
orofacial cleft 11 · score 0.73
heel bone mineral density · score 0.52
refractive error measurement · score 0.48
bone quantitative ultrasound measurement · score 0.47
colorectal cancer · score 0.47
Stickler syndrome · score 0.46
neurodegenerative disease · score 0.46
FEV/FVC ratio · score 0.46
refractive error · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12644-F1	alphafold	PREDICTED	78.51	—

Amino-acid sequence (408 residues)

MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards