Bone morphogenetic protein 3 (BMP3)

About Bone morphogenetic protein 3

Bone morphogenetic protein 3 (BMP3) is a protein from Homo sapiens identified by UniProt accession P12645, 472 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Bone morphogenetic protein 3
UniProt accession	P12645
Gene	BMP3
Organism	Homo sapiens
Length	472 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

Myopia · score 0.46
refractive error · score 0.43
refractive error measurement · score 0.41
age at onset · score 0.40
cataract · score 0.40
body height · score 0.38
hair color · score 0.17
schizophrenia · score 0.14
Rheumatoid arthritis · score 0.08
immature platelet fraction · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12645-F1	alphafold	PREDICTED	65.06	—

Amino-acid sequence (472 residues)

MAGASRLLFL WLGCFCVSLA QGERPKPPFP ELRKAVPGDR TAGGGPDSEL QPQDKVSEHM LRLYDRYSTV QAARTPGSLE GGSQPWRPRL LREGNTVRSF RAAAAETLER KGLYIFNLTS LTKSENILSA TLYFCIGELG NISLSCPVSG GCSHHAQRKH IQIDLSAWTL KFSRNQSQLL GHLSVDMAKS HRDIMSWLSK DITQLLRKAK ENEEFLIGFN ITSKGRQLPK RRLPFPEPYI LVYANDAAIS EPESVVSSLQ GHRNFPTGTV PKWDSHIRAA LSIERRKKRS TGVLLPLQNN ELPGAEYQYK KDEVWEERKP YKTLQAQAPE KSKNKKKQRK GPHRKSQTLQ FDEQTLKKAR RKQWIEPRNC ARRYLKVDFA DIGWSEWIIS PKSFDAYYCS GACQFPMPKS LKPSNHATIQ SIVRAVGVVP GIPEPCCVPE KMSSLSILFF DENKNVVLKV YPNMTVESCA CR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards