About 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA) is a protein
from Homo sapiens identified by UniProt accession
P12694, 445 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial |
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| UniProt accession | P12694 |
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| Gene | BCKDHA |
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| Organism | Homo sapiens |
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| Length | 445 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (80)
Diseases linked to this target (Open Targets).
- maple syrup urine disease type 1A · score 0.83
- maple syrup urine disease · score 0.73
- genetic disorder · score 0.51
- intermediate maple syrup urine disease · score 0.37
- thiamine-responsive maple syrup urine disease · score 0.37
- classic maple syrup urine disease · score 0.37
- intermittent maple syrup urine disease · score 0.37
- reticulocyte count · score 0.31
- body height · score 0.29
- BMI-adjusted waist circumference · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12694-F1 | alphafold | PREDICTED | 91.58 | — |
Amino-acid sequence (445 residues)
MAVAIAAARV WRLNRGLSQA ALLLLRQPGA RGLARSHPPR QQQQFSSLDD KPQFPGASAE FIDKLEFIQP NVISGIPIYR VMDRQGQIIN PSEDPHLPKE KVLKLYKSMT LLNTMDRILY ESQRQGRISF YMTNYGEEGT HVGSAAALDN TDLVFGQYRE AGVLMYRDYP LELFMAQCYG NISDLGKGRQ MPVHYGCKER HFVTISSPLA TQIPQAVGAA YAAKRANANR VVICYFGEGA ASEGDAHAGF NFAATLECPI IFFCRNNGYA ISTPTSEQYR GDGIAARGPG YGIMSIRVDG NDVFAVYNAT KEARRRAVAE NQPFLIEAMT YRIGHHSTSD DSSAYRSVDE VNYWDKQDHP ISRLRHYLLS QGWWDEEQEK AWRKQSRRKV MEAFEQAERK PKPNPNLLFS DVYQEMPAQL RKQQESLARH LQTYGEHYPL DHFDK
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