About Eosinophil cationic protein
Eosinophil cationic protein (RNASE3) is a protein
from Homo sapiens identified by UniProt accession
P12724, 160 residues long.
MolForge cross-references it against 0 known binders and
342 disease associations.
Target properties
| Protein name | Eosinophil cationic protein |
|---|
| UniProt accession | P12724 |
|---|
| Gene | RNASE3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 160 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (342)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.33
- neuroinflammatory disorder · score 0.26
- nose morphology measurement · score 0.20
- eosinophil cationic protein measurement · score 0.20
- lung adenocarcinoma · score 0.18
- ovarian cancer · score 0.18
- squamous cell lung carcinoma · score 0.14
- head and neck squamous cell carcinoma · score 0.12
- breast adenocarcinoma · score 0.10
- ulcerative colitis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12724-F1 | alphafold | PREDICTED | 90.07 | — |
Amino-acid sequence (160 residues)
MVPKLFTSQI CLLLLLGLMG VEGSLHARPP QFTRAQWFAI QHISLNPPRC TIAMRAINNY RWRCKNQNTF LRTTFANVVN VCGNQSIRCP HNRTLNNCHR SRFRVPLLHC DLINPGAQNI SNCTYADRPG RRFYVVACDN RDPRDSPRYP VVPVHLDTTI
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