About Ski oncogene
Ski oncogene (SKI) is a protein
from Homo sapiens identified by UniProt accession
P12755, 728 residues long.
MolForge cross-references it against 0 known binders and
173 disease associations.
Target properties
| Protein name | Ski oncogene |
|---|
| UniProt accession | P12755 |
|---|
| Gene | SKI |
|---|
| Organism | Homo sapiens |
|---|
| Length | 728 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (173)
Diseases linked to this target (Open Targets).
- Shprintzen-Goldberg syndrome · score 0.84
- genetic disorder · score 0.47
- familial thoracic aortic aneurysm and aortic dissection · score 0.47
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.47
- Schinzel-Giedion syndrome · score 0.46
- vital capacity · score 0.42
- platelet count · score 0.42
- reticulocyte count · score 0.41
- serum alanine aminotransferase measurement · score 0.40
- platelet component distribution width · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12755-F1 | alphafold | PREDICTED | 65.73 | — |
Amino-acid sequence (728 residues)
MEAAAGGRGC FQPHPGLQKT LEQFHLSSMS SLGGPAAFSA RWAQEAYKKE SAKEAGAAAV PAPVPAATEP PPVLHLPAIQ PPPPVLPGPF FMPSDRSTER CETVLEGETI SCFVVGGEKR LCLPQILNSV LRDFSLQQIN AVCDELHIYC SRCTADQLEI LKVMGILPFS APSCGLITKT DAERLCNALL YGGAYPPPCK KELAASLALG LELSERSVRV YHECFGKCKG LLVPELYSSP SAACIQCLDC RLMYPPHKFV VHSHKALENR TCHWGFDSAN WRAYILLSQD YTGKEEQARL GRCLDDVKEK FDYGNKYKRR VPRVSSEPPA SIRPKTDDTS SQSPAPSEKD KPSSWLRTLA GSSNKSLGCV HPRQRLSAFR PWSPAVSASE KELSPHLPAL IRDSFYSYKS FETAVAPNVA LAPPAQQKVV SSPPCAAAVS RAPEPLATCT QPRKRKLTVD TPGAPETLAP VAAPEEDKDS EAEVEVESRE EFTSSLSSLS SPSFTSSSSA KDLGSPGARA LPSAVPDAAA PADAPSGLEA ELEHLRQALE GGLDTKEAKE KFLHEVVKMR VKQEEKLSAA LQAKRSLHQE LEFLRVAKKE KLREATEAKR NLRKEIERLR AENEKKMKEA NESRLRLKRE LEQARQARVC DKGCEAGRLR AKYSAQIEDL QVKLQHAEAD REQLRADLLR EREAREHLEK VVKELQEQLW PRARPEAAGS EGAAELEP
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