Defensin alpha 4 (DEFA4)

About Defensin alpha 4

Defensin alpha 4 (DEFA4) is a protein from Homo sapiens identified by UniProt accession P12838, 97 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Defensin alpha 4
UniProt accession	P12838
Gene	DEFA4
Organism	Homo sapiens
Length	97 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

basophil count · score 0.34
monocyte count · score 0.33
basophil percentage of leukocytes · score 0.32
monocyte percentage of leukocytes · score 0.24
cutaneous melanoma · score 0.22
lung adenocarcinoma · score 0.22
IGA glomerulonephritis · score 0.17
squamous cell lung carcinoma · score 0.16
head and neck squamous cell carcinoma · score 0.15
gastric adenocarcinoma · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12838-F1	alphafold	PREDICTED	69.23	—

Amino-acid sequence (97 residues)

MRIIALLAAI LLVALQVRAG PLQARGDEAP GQEQRGPEDQ DISISFAWDK SSALQVSGST RGMVCSCRLV FCRRTELRVG NCLIGGVSFT YCCTRVD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards