About Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene tyrosine-protein kinase Src (SRC) is a protein
from Homo sapiens identified by UniProt accession
P12931, 536 residues long.
MolForge cross-references it against 0 known binders and
986 disease associations.
Target properties
| Protein name | Proto-oncogene tyrosine-protein kinase Src |
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| UniProt accession | P12931 |
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| Gene | SRC |
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| Organism | Homo sapiens |
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| Length | 536 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (986)
Diseases linked to this target (Open Targets).
- cancer · score 0.63
- chronic myelogenous leukemia · score 0.60
- neoplasm · score 0.58
- actinic keratosis · score 0.57
- acute lymphoblastic leukemia · score 0.57
- Noonan syndrome · score 0.53
- hypertrophic cardiomyopathy · score 0.50
- Costello syndrome · score 0.50
- medullary thyroid gland carcinoma · score 0.49
- thyroid cancer · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12931-F1 | alphafold | PREDICTED | 83.46 | — |
Amino-acid sequence (536 residues)
MGSNKSKPKD ASQRRRSLEP AENVHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD WWLAHSLSTG QTGYIPSNYV APSDSIQAEE WYFGKITRRE SERLLLNAEN PRGTFLVRES ETTKGAYCLS VSDFDNAKGL NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL CHRLTTVCPT SKPQTQGLAK DAWEIPRESL RLEVKLGQGC FGEVWMGTWN GTTRVAIKTL KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKGETGKY LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN LVCKVADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELTT KGRVPYPGMV NREVLDQVER GYRMPCPPEC PESLHDLMCQ CWRKEPEERP TFEYLQAFLE DYFTSTEPQY QPGENL
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