Xaa-Pro dipeptidase (PEPD)

About Xaa-Pro dipeptidase

Xaa-Pro dipeptidase (PEPD) is a protein from Homo sapiens identified by UniProt accession P12955, 493 residues long. MolForge cross-references it against 0 known binders and 410 disease associations.

Target properties

Protein name	Xaa-Pro dipeptidase
UniProt accession	P12955
Gene	PEPD
Organism	Homo sapiens
Length	493 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (410)

Diseases linked to this target (Open Targets).

prolidase deficiency · score 0.82
body fat percentage · score 0.46
high density lipoprotein cholesterol measurement · score 0.45
sex hormone-binding globulin measurement · score 0.43
body mass index · score 0.42
aspartate aminotransferase measurement · score 0.41
serum alanine aminotransferase measurement · score 0.40
systolic blood pressure · score 0.39
appendicular lean mass · score 0.39
fat body mass · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12955-F1	alphafold	PREDICTED	97.43	—

Amino-acid sequence (493 residues)

MAAATGPSFW LGNETLKVPL ALFALNRQRL CERLRKNPAV QAGSIVVLQG GEETQRYCTD TGVLFRQESF FHWAFGVTEP GCYGVIDVDT GKSTLFVPRL PASHATWMGK IHSKEHFKEK YAVDDVQYVD EIASVLTSQK PSVLLTLRGV NTDSGSVCRE ASFDGISKFE VNNTILHPEI VECRVFKTDM ELEVLRYTNK ISSEAHREVM KAVKVGMKEY ELESLFEHYC YSRGGMRHSS YTCICGSGEN SAVLHYGHAG APNDRTIQNG DMCLFDMGGE YYCFASDITC SFPANGKFTA DQKAVYEAVL RSSRAVMGAM KPGVWWPDMH RLADRIHLEE LAHMGILSGS VDAMVQAHLG AVFMPHGLGH FLGIDVHDVG GYPEGVERID EPGLRSLRTA RHLQPGMVLT VEPGIYFIDH LLDEALADPA RASFLNREVL QRFRGFGGVR IEEDVVVTDS GIELLTCVPR TVEEIEACMA GCDKAFTPFS GPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards