About DNA repair protein Ku70
DNA repair protein Ku70 (XRCC6) is a protein
from Homo sapiens identified by UniProt accession
P12956, 609 residues long.
MolForge cross-references it against 0 known binders and
319 disease associations.
Target properties
| Protein name | DNA repair protein Ku70 |
|---|
| UniProt accession | P12956 |
|---|
| Gene | XRCC6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 609 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (319)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.50
- neurodegenerative disease · score 0.44
- lung adenocarcinoma · score 0.25
- mathematical ability · score 0.23
- breast adenocarcinoma · score 0.23
- endometrial cancer · score 0.18
- ovarian cancer · score 0.18
- thyroid gland adenocarcinoma · score 0.18
- self reported educational attainment · score 0.14
- pulse pressure measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12956-F1 | alphafold | PREDICTED | 84.41 | — |
Amino-acid sequence (609 residues)
MSGWESYYKT EGDEEAEEEQ EENLEASGDY KYSGRDSLIF LVDASKAMFE SQSEDELTPF DMSIQCIQSV YISKIISSDR DLLAVVFYGT EKDKNSVNFK NIYVLQELDN PGAKRILELD QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC ANLFSDVQFK MSHKRIMLFT NEDNPHGNDS AKASRARTKA GDLRDTGIFL DLMHLKKPGG FDISLFYRDI ISIAEDEDLR VHFEESSKLE DLLRKVRAKE TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR ETNEPVKTKT RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF KPLVLLKKHH YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY TPRRNIPPYF VALVPQEEEL DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE KIMATPEQVG KMKAIVEKLR FTYRSDSFEN PVLQQHFRNL EALALDLMEP EQAVDLTLPK VEAMNKRLGS LVDEFKELVY PPDYNPEGKV TKRKHDNEGS GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL KSGLKKQELL EALTKHFQD
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