About Uracil-DNA glycosylase
Uracil-DNA glycosylase (UNG) is a protein
from Homo sapiens identified by UniProt accession
P13051, 313 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Uracil-DNA glycosylase |
|---|
| UniProt accession | P13051 |
|---|
| Gene | UNG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 313 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (186)
Diseases linked to this target (Open Targets).
- hyper-IgM syndrome type 5 · score 0.74
- hyper-IgM syndrome · score 0.15
- metabolite measurement · score 0.12
- Hereditary breast and ovarian cancer syndrome · score 0.12
- hereditary breast ovarian cancer syndrome · score 0.12
- neoplasm · score 0.08
- cancer · score 0.06
- cystatin C measurement · score 0.05
- infection · score 0.05
- infect · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13051-F1 | alphafold | PREDICTED | 85.30 | — |
Amino-acid sequence (313 residues)
MIGQKTLYSF FSPSPARKRH APSPEPAVQG TGVAGVPEES GDAAAIPAKK APAGQEEPGT PPSSPLSAEQ LDRIQRNKAA ALLRLAARNV PVGFGESWKK HLSGEFGKPY FIKLMGFVAE ERKHYTVYPP PHQVFTWTQM CDIKDVKVVI LGQDPYHGPN QAHGLCFSVQ RPVPPPPSLE NIYKELSTDI EDFVHPGHGD LSGWAKQGVL LLNAVLTVRA HQANSHKERG WEQFTDAVVS WLNQNSNGLV FLLWGSYAQK KGSAIDRKRH HVLQTAHPSP LSVYRGFFGC RHFSKTNELL QKSGKKPIDW KEL
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