About Nuclear receptor subfamily 2 group C member 1
Nuclear receptor subfamily 2 group C member 1 (NR2C1) is a protein
from Homo sapiens identified by UniProt accession
P13056, 603 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 2 group C member 1 |
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| UniProt accession | P13056 |
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| Gene | NR2C1 |
|---|
| Organism | Homo sapiens |
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| Length | 603 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (78)
Diseases linked to this target (Open Targets).
- Flexion contracture · score 0.26
- Alzheimer disease · score 0.25
- neurodegenerative disease · score 0.24
- lysosomal storage disease · score 0.24
- multiple sclerosis · score 0.24
- Parkinson disease · score 0.24
- coronary artery disease · score 0.19
- FEV/FVC ratio · score 0.14
- platelet count · score 0.14
- chronic obstructive pulmonary disease · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13056-F1 | alphafold | PREDICTED | 64.39 | — |
Amino-acid sequence (603 residues)
MATIEEIAHQ IIEQQMGEIV TEQQTGQKIQ IVTALDHNTQ GKQFILTNHD GSTPSKVILA RQDSTPGKVF LTTPDAAGVN QLFFTTPDLS AQHLQLLTDN SPDQGPNKVF DLCVVCGDKA SGRHYGAVTC EGCKGFFKRS IRKNLVYSCR GSKDCIINKH HRNRCQYCRL QRCIAFGMKQ DSVQCERKPI EVSREKSSNC AASTEKIYIR KDLRSPLTAT PTFVTDSEST RSTGLLDSGM FMNIHPSGVK TESAVLMTSD KAESCQGDLS TLANVVTSLA NLGKTKDLSQ NSNEMSMIES LSNDDTSLCE FQEMQTNGDV SRAFDTLAKA LNPGESTACQ SSVAGMEGSV HLITGDSSIN YTEKEGPLLS DSHVAFRLTM PSPMPEYLNV HYIGESASRL LFLSMHWALS IPSFQALGQE NSISLVKAYW NELFTLGLAQ CWQVMNVATI LATFVNCLHN SLQQDKMSTE RRKLLMEHIF KLQEFCNSMV KLCIDGYEYA YLKAIVLFSP DHPSLENMEQ IEKFQEKAYV EFQDYITKTY PDDTYRLSRL LLRLPALRLM NATITEELFF KGLIGNIRID SVIPHILKME PADYNSQIIG HSI
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