About Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) is a protein
from Homo sapiens identified by UniProt accession
P13073, 169 residues long.
MolForge cross-references it against 0 known binders and
153 disease associations.
Target properties
| Protein name | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
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| UniProt accession | P13073 |
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| Gene | COX4I1 |
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| Organism | Homo sapiens |
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| Length | 169 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (153)
Diseases linked to this target (Open Targets).
- mitochondrial complex 4 deficiency, nuclear type 16 · score 0.59
- neurodegenerative disease · score 0.52
- Isolated cytochrome C oxidase deficiency · score 0.37
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.33
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.33
- eosinophil count · score 0.26
- squamous cell lung carcinoma · score 0.18
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.18
- eosinophil percentage of leukocytes · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13073-F1 | alphafold | PREDICTED | 88.63 | — |
Amino-acid sequence (169 residues)
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK
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