Interferon-induced transmembrane protein 1 (IFITM1)

About Interferon-induced transmembrane protein 1

Interferon-induced transmembrane protein 1 (IFITM1) is a protein from Homo sapiens identified by UniProt accession P13164, 125 residues long. MolForge cross-references it against 0 known binders and 335 disease associations.

Target properties

Protein name	Interferon-induced transmembrane protein 1
UniProt accession	P13164
Gene	IFITM1
Organism	Homo sapiens
Length	125 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (335)

Diseases linked to this target (Open Targets).

neutrophil percentage of leukocytes · score 0.19
FEV/FVC ratio · score 0.19
thyroid gland adenocarcinoma · score 0.18
basophil count · score 0.18
neutrophil count · score 0.17
monocyte count · score 0.17
leukocyte count · score 0.17
monocyte percentage of leukocytes · score 0.17
erythrocyte count · score 0.17
neurodegenerative disease · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13164-F1	alphafold	PREDICTED	64.90	—

Amino-acid sequence (125 residues)

MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF ILLLVFGSVT VYHIMLQIIQ EKRGY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards