About 5-aminolevulinate synthase, non-specific, mitochondrial
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) is a protein
from Homo sapiens identified by UniProt accession
P13196, 640 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | 5-aminolevulinate synthase, non-specific, mitochondrial |
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| UniProt accession | P13196 |
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| Gene | ALAS1 |
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| Organism | Homo sapiens |
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| Length | 640 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (133)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- Acute hepatic porphyria · score 0.44
- liver disease · score 0.37
- acute intermittent porphyria · score 0.28
- hereditary coproporphyria · score 0.26
- porphyria due to ALA dehydratase deficiency · score 0.26
- wellbeing measurement · score 0.15
- bipolar disorder · score 0.12
- type 2 diabetes mellitus · score 0.12
- depressive symptom measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13196-F1 | alphafold | PREDICTED | 79.27 | — |
Amino-acid sequence (640 residues)
MESVVRRCPF LSRVPQAFLQ KAGKSLLFYA QNCPKMMEVG AKPAPRALST AAVHYQQIKE TPPASEKDKT AKAKVQQTPD GSQQSPDGTQ LPSGHPLPAT SQGTASKCPF LAAQMNQRGS SVFCKASLEL QEDVQEMNAV RKEVAETSAG PSVVSVKTDG GDPSGLLKNF QDIMQKQRPE RVSHLLQDNL PKSVSTFQYD RFFEKKIDEK KNDHTYRVFK TVNRRAHIFP MADDYSDSLI TKKQVSVWCS NDYLGMSRHP RVCGAVMDTL KQHGAGAGGT RNISGTSKFH VDLERELADL HGKDAALLFS SCFVANDSTL FTLAKMMPGC EIYSDSGNHA SMIQGIRNSR VPKYIFRHND VSHLRELLQR SDPSVPKIVA FETVHSMDGA VCPLEELCDV AHEFGAITFV DEVHAVGLYG ARGGGIGDRD GVMPKMDIIS GTLGKAFGCV GGYIASTSSL IDTVRSYAAG FIFTTSLPPM LLAGALESVR ILKSAEGRVL RRQHQRNVKL MRQMLMDAGL PVVHCPSHII PVRVADAAKN TEVCDELMSR HNIYVQAINY PTVPRGEELL RIAPTPHHTP QMMNYFLENL LVTWKQVGLE LKPHSSAECN FCRRPLHFEV MSEREKSYFS GLSKLVSAQA
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