About Platelet glycoprotein Ib beta chain
Platelet glycoprotein Ib beta chain (GP1BB) is a protein
from Homo sapiens identified by UniProt accession
P13224, 206 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | Platelet glycoprotein Ib beta chain |
|---|
| UniProt accession | P13224 |
|---|
| Gene | GP1BB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 206 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (119)
Diseases linked to this target (Open Targets).
- Bernard-Soulier syndrome · score 0.78
- mean platelet volume · score 0.68
- platelet count · score 0.68
- platelet component distribution width · score 0.65
- Macrothrombocytopenia · score 0.61
- Thrombocytopenia · score 0.48
- platelet crit · score 0.47
- autosomal dominant macrothrombocytopenia · score 0.39
- heel bone mineral density · score 0.18
- bone quantitative ultrasound measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13224-F1 | alphafold | PREDICTED | 87.96 | — |
Amino-acid sequence (206 residues)
MGSGPRGALS LLLLLLAPPS RPAAGCPAPC SCAGTLVDCG RRGLTWASLP TAFPVDTTEL VLTGNNLTAL PPGLLDALPA LRTAHLGANP WRCDCRLVPL RAWLAGRPER APYRDLRCVA PPALRGRLLP YLAEDELRAA CAPGPLCWGA LAAQLALLGL GLLHALLLVL LLCRLRRLRA RARARAAARL SLTDPLVAER AGTDES
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