About Homeobox protein Hox-D8
Homeobox protein Hox-D8 (HOXD8) is a protein
from Homo sapiens identified by UniProt accession
P13378, 290 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Homeobox protein Hox-D8 |
|---|
| UniProt accession | P13378 |
|---|
| Gene | HOXD8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 290 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (88)
Diseases linked to this target (Open Targets).
- hair shape measurement · score 0.29
- balding measurement · score 0.27
- erythrocyte count · score 0.26
- alopecia · score 0.22
- androgenetic alopecia · score 0.22
- hair colour measurement · score 0.22
- hemoglobin measurement · score 0.09
- urate measurement · score 0.08
- facial morphology measurement · score 0.08
- central nervous system cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13378-F1 | alphafold | PREDICTED | 61.71 | — |
Amino-acid sequence (290 residues)
MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFAPEV GGRHAAAAAA LQLYGNSAAG FPHAPPQAHA HPHPSPPPSG TGCGGREGRG QEYFHPGGGS PAAAYQAAPP PPPHPPPPPP PPPCGGIACH GEPAKFYGYD NLQRQPIFTT QQEAELVQYP DCKSSSGNIG EDPDHLNQSS SPSQMFPWMR PQAAPGRRRG RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ VKIWFQNRRM KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN
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