About Protein Cripto
Protein Cripto (CRIPTO) is a protein
from Homo sapiens identified by UniProt accession
P13385, 188 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Protein Cripto |
|---|
| UniProt accession | P13385 |
|---|
| Gene | CRIPTO |
|---|
| Organism | Homo sapiens |
|---|
| Length | 188 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (121)
Diseases linked to this target (Open Targets).
- septopreoptic holoprosencephaly · score 0.37
- lobar holoprosencephaly · score 0.37
- microform holoprosencephaly · score 0.37
- semilobar holoprosencephaly · score 0.37
- midline interhemispheric variant of holoprosencephaly · score 0.37
- alobar holoprosencephaly · score 0.37
- protein measurement · score 0.25
- teratocarcinoma-derived growth factor 1 measurement · score 0.24
- cerebrospinal fluid biomarker measurement · score 0.17
- blood protein measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13385-F1 | alphafold | PREDICTED | 68.03 | — |
Amino-acid sequence (188 residues)
MDCRKMARFS YSVIWIMAIS KVFELGLVAG LGHQEFARPS RGYLAFRDDS IWPQEEPAIR PRSSQRVPPM GIQHSKELNR TCCLNGGTCM LGSFCACPPS FYGRNCEHDV RKENCGSVPH DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD GLVMDEHLVA SRTPELPPSA RTTTFMLVGI CLSIQSYY
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