Lysosome-associated membrane glycoprotein 2 (LAMP2)

About Lysosome-associated membrane glycoprotein 2

Lysosome-associated membrane glycoprotein 2 (LAMP2) is a protein from Homo sapiens identified by UniProt accession P13473, 410 residues long. MolForge cross-references it against 0 known binders and 485 disease associations.

Target properties

Protein name	Lysosome-associated membrane glycoprotein 2
UniProt accession	P13473
Gene	LAMP2
Organism	Homo sapiens
Length	410 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (485)

Diseases linked to this target (Open Targets).

Glycogen Storage Disease Type 2b · score 0.83
hypertrophic cardiomyopathy · score 0.54
Abnormality of the cardiovascular system · score 0.54
dilated cardiomyopathy · score 0.49
cardiomyopathy · score 0.49
Pigmentary retinopathy · score 0.37
isolated noncompaction of the ventricular myocardium · score 0.34
familial hypertrophic cardiomyopathy · score 0.31
breast adenocarcinoma · score 0.25
Intellectual disability · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13473-F1	alphafold	PREDICTED	83.17	—

Amino-acid sequence (410 residues)

MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL RVQPFNVTQG KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL KHHHAGYEQF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards