About Cytochrome b-245 light chain
Cytochrome b-245 light chain (CYBA) is a protein
from Homo sapiens identified by UniProt accession
P13498, 195 residues long.
MolForge cross-references it against 0 known binders and
344 disease associations.
Target properties
| Protein name | Cytochrome b-245 light chain |
|---|
| UniProt accession | P13498 |
|---|
| Gene | CYBA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 195 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (344)
Diseases linked to this target (Open Targets).
- chronic granulomatous disease · score 0.67
- Autoimmune polyendocrinopathy type 1 · score 0.34
- autoimmune polyendocrine syndrome type 1 · score 0.34
- sunburn · score 0.20
- genetic disorder · score 0.19
- oral squamous cell carcinoma · score 0.09
- Rheumatoid arthritis · score 0.08
- mean corpuscular volume · score 0.07
- lung adenocarcinoma · score 0.07
- isolated agammaglobulinemia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13498-F1 | alphafold | PREDICTED | 76.88 | — |
Amino-acid sequence (195 residues)
MGQIEWAMWA NEQALASGLI LITGGIVATA GRFTQWYFGA YSIVAGVFVC LLEYPRGKRK KGSTMERWGQ KYMTAVVKLF GPFTRNYYVR AVLHLLLSVP AGFLLATILG TACLAIASGI YLLAAVRGEQ WTPIEPKPRE RPQIGGTIKQ PPSNPPPRPP AEARKKPSEE EAAVAAGGPP GGPQVNPIPV TDEVV
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