Cytochrome P450 4B1 (CYP4B1)

About Cytochrome P450 4B1

Cytochrome P450 4B1 (CYP4B1) is a protein from Homo sapiens identified by UniProt accession P13584, 511 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

Target properties

Protein name	Cytochrome P450 4B1
UniProt accession	P13584
Gene	CYP4B1
Organism	Homo sapiens
Length	511 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

cutaneous melanoma · score 0.26
glioblastoma multiforme · score 0.23
lung adenocarcinoma · score 0.21
head and neck squamous cell carcinoma · score 0.13
serum metabolite measurement · score 0.12
urinary bladder cancer · score 0.11
urinary metabolite measurement · score 0.08
breast cancer · score 0.07
blood metabolite measurement · score 0.07
lung carcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13584-F1	alphafold	PREDICTED	94.08	—

Amino-acid sequence (511 residues)

MVPSFLSLSF SSLGLWASGL ILVLGFLKLI HLLLRRQTLA KAMDKFPGPP THWLFGHALE IQETGSLDKV VSWAHQFPYA HPLWFGQFIG FLNIYEPDYA KAVYSRGDPK APDVYDFFLQ WIGRGLLVLE GPKWLQHRKL LTPGFHYDVL KPYVAVFTES TRIMLDKWEE KAREGKSFDI FCDVGHMALN TLMKCTFGRG DTGLGHRDSS YYLAVSDLTL LMQQRLVSFQ YHNDFIYWLT PHGRRFLRAC QVAHDHTDQV IRERKAALQD EKVRKKIQNR RHLDFLDILL GARDEDDIKL SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQHR CREEVREILG DQDFFQWDDL GKMTYLTMCI KESFRLYPPV PQVYRQLSKP VTFVDGRSLP AGSLISMHIY ALHRNSAVWP DPEVFDSLRF STENASKRHP FAFMPFSAGP RNCIGQQFAM SEMKVVTAMC LLRFEFSLDP SRLPIKMPQL VLRSKNGFHL HLKPLGPGSG K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards