About Intercellular adhesion molecule 2
Intercellular adhesion molecule 2 (ICAM2) is a protein
from Homo sapiens identified by UniProt accession
P13598, 275 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | Intercellular adhesion molecule 2 |
|---|
| UniProt accession | P13598 |
|---|
| Gene | ICAM2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 275 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (146)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- lung adenocarcinoma · score 0.19
- endometrial cancer · score 0.18
- cutaneous melanoma · score 0.11
- neoplasm · score 0.10
- ulcerative colitis · score 0.08
- psoriasis · score 0.08
- sclerosing cholangitis · score 0.08
- Crohn's disease · score 0.08
- ankylosing spondylitis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13598-F1 | alphafold | PREDICTED | 87.11 | — |
Amino-acid sequence (275 residues)
MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ HLRQQRMGTY GVRAAWRRLP QAFRP
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