About Sodium/potassium-transporting ATPase subunit alpha-3
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) is a protein
from Homo sapiens identified by UniProt accession
P13637, 1013 residues long.
MolForge cross-references it against 0 known binders and
541 disease associations.
Target properties
| Protein name | Sodium/potassium-transporting ATPase subunit alpha-3 |
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| UniProt accession | P13637 |
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| Gene | ATP1A3 |
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| Organism | Homo sapiens |
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| Length | 1013 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (541)
Diseases linked to this target (Open Targets).
- alternating hemiplegia of childhood 2 · score 0.83
- dystonia 12 · score 0.82
- Rapid-onset dystonia-parkinsonism · score 0.78
- cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome · score 0.76
- Cerebellar ataxia - areflexia - pes cavus - optic atrophy - sensorineural hearing loss · score 0.75
- developmental and epileptic encephalopathy 99 · score 0.72
- alternating hemiplegia of childhood · score 0.62
- congestive heart failure · score 0.60
- atrial fibrillation · score 0.60
- ATP1A3-associated neurological disorder · score 0.59
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13637-F1 | alphafold | PREDICTED | 88.83 | — |
Amino-acid sequence (1013 residues)
MGDKKDDKDS PKKNKGKERR DLDDLKKEVA MTEHKMSVEE VCRKYNTDCV QGLTHSKAQE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF SILLWIGAIL CFLAYGIQAG TEDDPSGDNL YLGIVLAAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL VIREGEKMQV NAEEVVVGDL VEIKGGDRVP ADLRIISAHG CKVDNSSLTG ESEPQTRSPD CTHDNPLETR NITFFSTNCV EGTARGVVVA TGDRTVMGRI ATLASGLEVG KTPIAIEIEH FIQLITGVAV FLGVSFFILS LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTEDQSGTS FDKSSHTWVA LSHIAGLCNR AVFKGGQDNI PVLKRDVAGD ASESALLKCI ELSSGSVKLM RERNKKVAEI PFNSTNKYQL SIHETEDPND NRYLLVMKGA PERILDRCST ILLQGKEQPL DEEMKEAFQN AYLELGGLGE RVLGFCHYYL PEEQFPKGFA FDCDDVNFTT DNLCFVGLMS MIDPPRAAVP DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA KACVIHGTDL KDFTSEQIDE ILQNHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LLFIMANIPL PLGTITILCI DLGTDMVPAI SLAYEAAESD IMKRQPRNPR TDKLVNERLI SMAYGQIGMI QALGGFFSYF VILAENGFLP GNLVGIRLNW DDRTVNDLED SYGQQWTYEQ RKVVEFTCHT AFFVSIVVVQ WADLIICKTR RNSVFQQGMK NKILIFGLFE ETALAAFLSY CPGMDVALRM YPLKPSWWFC AFPYSFLIFV YDEIRKLILR RNPGGWVEKE TYY
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