About Keratin, type I cytoskeletal 10
Keratin, type I cytoskeletal 10 (KRT10) is a protein
from Homo sapiens identified by UniProt accession
P13645, 584 residues long.
MolForge cross-references it against 0 known binders and
392 disease associations.
Target properties
| Protein name | Keratin, type I cytoskeletal 10 |
|---|
| UniProt accession | P13645 |
|---|
| Gene | KRT10 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 584 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (392)
Diseases linked to this target (Open Targets).
- congenital reticular ichthyosiform erythroderma · score 0.72
- epidermolytic ichthyosis · score 0.67
- ichthyosis, annular epidermolytic 1 · score 0.62
- annular epidermolytic ichthyosis · score 0.59
- pachyonychia congenita · score 0.52
- Palmoplantar keratoderma · score 0.51
- epidermolytic hyperkeratosis 1 · score 0.47
- ichthyosis histrix, Lambert type · score 0.39
- autosomal dominant epidermolytic ichthyosis · score 0.38
- autosomal recessive epidermolytic ichthyosis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13645-F1 | alphafold | PREDICTED | 64.30 | — |
Amino-acid sequence (584 residues)
MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG GFSGGSFSRG SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG IFGGGSFGGG SFGGGSFGGG GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM QNLNDRLASY LDKVRALEES NYELEGKIKE WYEKHGNSHQ GEPRDYSKYY KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN EVALRQSVEA DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE IDNNIEQISS YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY CVQLSQIQAQ ISALEEQLQQ IRAETECQNT EYQQLLDIKI RLENEIQTYR SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG GSSGGGHGGG HGGSSGGGYG GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG GYGGGSSGGG SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY
Explore Keratin, type I cytoskeletal 10 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets