Keratin, type I cytoskeletal 13 (KRT13)

About Keratin, type I cytoskeletal 13

Keratin, type I cytoskeletal 13 (KRT13) is a protein from Homo sapiens identified by UniProt accession P13646, 458 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 13
UniProt accession	P13646
Gene	KRT13
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

White sponge nevus · score 0.55
genetic disorder · score 0.19
head and neck squamous cell carcinoma · score 0.19
glioblastoma multiforme · score 0.19
clear cell renal carcinoma · score 0.18
pancreatic adenocarcinoma · score 0.18
ovarian cancer · score 0.18
esophageal cancer · score 0.15
white sponge nevus 1 · score 0.13
oral squamous cell carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13646-F1	alphafold	PREDICTED	72.59	—

Amino-acid sequence (458 residues)

MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS CGFGGGAGSG FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL TGNEKITMQN LNDRLASYLE KVRALEEANA DLEVKIRDWH LKQSPASPER DYSPYYKTIE ELRDKILTAT IENNRVILEI DNARLAADDF RLKYENELAL RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK KNHEEEMKEF SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHTKS AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA ETECRYALQL QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ EIATYRSLLE GQDAKMIGFP SSAGSVSPRS TSVTTTSSAS VTTTSNASGR RTSDVRRP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards