About Keratin, type II cytoskeletal 5
Keratin, type II cytoskeletal 5 (KRT5) is a protein
from Homo sapiens identified by UniProt accession
P13647, 590 residues long.
MolForge cross-references it against 0 known binders and
518 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 5 |
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| UniProt accession | P13647 |
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| Gene | KRT5 |
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| Organism | Homo sapiens |
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| Length | 590 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (518)
Diseases linked to this target (Open Targets).
- epidermolysis bullosa simplex 2C, localized · score 0.77
- epidermolysis bullosa simplex 2A, generalized severe · score 0.76
- epidermolysis bullosa simplex 2B, generalized intermediate · score 0.75
- Epidermolysis bullosa simplex with mottled pigmentation · score 0.69
- Epidermolysis bullosa simplex, Dowling-Meara type · score 0.69
- epidermolysis bullosa simplex · score 0.68
- epidermolysis bullosa simplex 2d, generalized, intermediate or severe, autosomal recessive · score 0.67
- Localized epidermolysis bullosa simplex · score 0.67
- Generalized epidermolysis bullosa simplex, non-Dowling-Meara type · score 0.66
- Epidermolysis bullosa simplex with circinate migratory erythema · score 0.65
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13647-F1 | alphafold | PREDICTED | 65.44 | — |
Amino-acid sequence (590 residues)
MSRQSSVSFR SGGSRSFSTA SAITPSVSRT SFTSVSRSGG GGGGGFGRVS LAGACGVGGY GSRSLYNLGG SKRISISTSG GSFRNRFGAG AGGGYGFGGG AGSGFGFGGG AGGGFGLGGG AGFGGGFGGP GFPVCPPGGI QEVTVNQSLL TPLNLQIDPS IQRVRTEERE QIKTLNNKFA SFIDKVRFLE QQNKVLDTKW TLLQEQGTKT VRQNLEPLFE QYINNLRRQL DSIVGERGRL DSELRNMQDL VEDFKNKYED EINKRTTAEN EFVMLKKDVD AAYMNKVELE AKVDALMDEI NFMKMFFDAE LSQMQTHVSD TSVVLSMDNN RNLDLDSIIA EVKAQYEEIA NRSRTEAESW YQTKYEELQQ TAGRHGDDLR NTKHEISEMN RMIQRLRAEI DNVKKQCANL QNAIADAEQR GELALKDARN KLAELEEALQ KAKQDMARLL REYQELMNTK LALDVEIATY RKLLEGEECR LSGEGVGPVN ISVVTSSVSS GYGSGSGYGG GLGGGLGGGL GGGLAGGSSG SYYSSSSGGV GLGGGLSVGG SGFSASSGRG LGVGFGSGGG SSSSVKFVST TSSSRKSFKS
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