About Prolyl 4-hydroxylase subunit alpha-1
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) is a protein
from Homo sapiens identified by UniProt accession
P13674, 534 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Prolyl 4-hydroxylase subunit alpha-1 |
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| UniProt accession | P13674 |
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| Gene | P4HA1 |
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| Organism | Homo sapiens |
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| Length | 534 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (126)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- breast adenocarcinoma · score 0.23
- total cholesterol measurement · score 0.20
- systolic blood pressure · score 0.12
- body height · score 0.12
- neoplasm · score 0.11
- lung adenocarcinoma · score 0.10
- cancer · score 0.10
- endometrial cancer · score 0.09
- breast cancer · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13674-F1 | alphafold | PREDICTED | 89.96 | — |
Amino-acid sequence (534 residues)
MIWYILIIGI LLPQSLAHPG FFTSIGQMTD LIHTEKDLVT SLKDYIKAEE DKLEQIKKWA EKLDRLTSTA TKDPEGFVGH PVNAFKLMKR LNTEWSELEN LVLKDMSDGF ISNLTIQRQY FPNDEDQVGA AKALLRLQDT YNLDTDTISK GNLPGVKHKS FLTAEDCFEL GKVAYTEADY YHTELWMEQA LRQLDEGEIS TIDKVSVLDY LSYAVYQQGD LDKALLLTKK LLELDPEHQR ANGNLKYFEY IMAKEKDVNK SASDDQSDQK TTPKKKGVAV DYLPERQKYE MLCRGEGIKM TPRRQKKLFC RYHDGNRNPK FILAPAKQED EWDKPRIIRF HDIISDAEIE IVKDLAKPRL RRATISNPIT GDLETVHYRI SKSAWLSGYE NPVVSRINMR IQDLTGLDVS TAEELQVANY GVGGQYEPHF DFARKDEPDA FKELGTGNRI ATWLFYMSDV SAGGATVFPE VGASVWPKKG TAVFWYNLFA SGEGDYSTRH AACPVLVGNK WVSNKWLHER GQEFRRPCTL SELE
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