Translationally-controlled tumor protein (TPT1)

About Translationally-controlled tumor protein

Translationally-controlled tumor protein (TPT1) is a protein from Homo sapiens identified by UniProt accession P13693, 172 residues long. MolForge cross-references it against 0 known binders and 156 disease associations.

Target properties

Protein name	Translationally-controlled tumor protein
UniProt accession	P13693
Gene	TPT1
Organism	Homo sapiens
Length	172 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (156)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
Herpetic encephalitis · score 0.26
pathological myopia · score 0.26
Red cell distribution width · score 0.22
neoplasm · score 0.11
cancer · score 0.08
hepatocellular carcinoma · score 0.08
breast cancer · score 0.08
coronary artery disease · score 0.07
Corpuscular Hemoglobin Content · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13693-F1	alphafold	PREDICTED	90.60	—

Amino-acid sequence (172 residues)

MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFFIGENM NPDGMVALLD YREDGVTPYM IFFKDGLEME KC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards