Delta-aminolevulinic acid dehydratase (ALAD)

About Delta-aminolevulinic acid dehydratase

Delta-aminolevulinic acid dehydratase (ALAD) is a protein from Homo sapiens identified by UniProt accession P13716, 330 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	Delta-aminolevulinic acid dehydratase
UniProt accession	P13716
Gene	ALAD
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (134)

Diseases linked to this target (Open Targets).

porphyria due to ALA dehydratase deficiency · score 0.81
reticulocyte count · score 0.39
reticulocyte measurement · score 0.37
neurodegenerative disease · score 0.24
blood lead measurement · score 0.19
genetic disorder · score 0.19
systolic blood pressure · score 0.06
body height · score 0.06
Congenital dyserythropoietic anemia type I · score 0.04
dominant beta-thalassemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13716-F1	alphafold	PREDICTED	96.29	—

Amino-acid sequence (330 residues)

MQPQSVLHSG YFHPLLRAWQ TATTTLNASN LIYPIFVTDV PDDIQPITSL PGVARYGVKR LEEMLRPLVE EGLRCVLIFG VPSRVPKDER GSAADSEESP AIEAIHLLRK TFPNLLVACD VCLCPYTSHG HCGLLSENGA FRAEESRQRL AEVALAYAKA GCQVVAPSDM MDGRVEAIKE ALMAHGLGNR VSVMSYSAKF ASCFYGPFRD AAKSSPAFGD RRCYQLPPGA RGLALRAVDR DVREGADMLM VKPGMPYLDI VREVKDKHPD LPLAVYHVSG EFAMLWHGAQ AGAFDLKAAV LEAMTAFRRA GADIIITYYT PQLLQWLKEE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards