About Bone marrow proteoglycan
Bone marrow proteoglycan (PRG2) is a protein
from Homo sapiens identified by UniProt accession
P13727, 222 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Bone marrow proteoglycan |
|---|
| UniProt accession | P13727 |
|---|
| Gene | PRG2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 222 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.31
- mean corpuscular hemoglobin concentration · score 0.30
- pappalysin‐1 measurement · score 0.26
- eosinophil count · score 0.22
- blood protein measurement · score 0.19
- eosinophil percentage of leukocytes · score 0.17
- prostate cancer · score 0.09
- sum of eosinophil and basophil counts · score 0.07
- mean corpuscular hemoglobin · score 0.05
- Recurrent infection due to specific granule deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13727-F1 | alphafold | PREDICTED | 75.94 | — |
Amino-acid sequence (222 residues)
MKLPLLLALL FGAVSALHLR SETSTFETPL GAKTLPEDEE TPEQEMEETP CRELEEEEEW GSGSEDASKK DGAVESISVP DMVDKNLTCP EEEDTVKVVG IPGCQTCRYL LVRSLQTFSQ AWFTCRRCYR GNLVSIHNFN INYRIQCSVS ALNQGQVWIG GRITGSGRCR RFQWVDGSRW NFAYWAAHQP WSRGGHCVAL CTRGGHWRRA HCLRRLPFIC SY
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