About Plastin-2
Plastin-2 (LCP1) is a protein
from Homo sapiens identified by UniProt accession
P13796, 627 residues long.
MolForge cross-references it against 0 known binders and
265 disease associations.
Target properties
| Protein name | Plastin-2 |
|---|
| UniProt accession | P13796 |
|---|
| Gene | LCP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 627 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (265)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.42
- hereditary breast ovarian cancer syndrome · score 0.34
- Hereditary breast and ovarian cancer syndrome · score 0.34
- urate measurement · score 0.24
- bone density · score 0.24
- MAP kinase-activated protein kinase 3 measurement · score 0.24
- blood protein measurement · score 0.23
- lymphocyte percentage of leukocytes · score 0.23
- oral squamous cell carcinoma · score 0.20
- lung carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13796-F1 | alphafold | PREDICTED | 89.62 | — |
Amino-acid sequence (627 residues)
MARGSVSDEE MMELREAFAK VDTDGNGYIS FNELNDLFKA ACLPLPGYRV REITENLMAT GDLDQDGRIS FDEFIKIFHG LKSTDVAKTF RKAINKKEGI CAIGGTSEQS SVGTQHSYSE EEKYAFVNWI NKALENDPDC RHVIPMNPNT NDLFNAVGDG IVLCKMINLS VPDTIDERTI NKKKLTPFTI QENLNLALNS ASAIGCHVVN IGAEDLKEGK PYLVLGLLWQ VIKIGLFADI ELSRNEALIA LLREGESLED LMKLSPEELL LRWANYHLEN AGCNKIGNFS TDIKDSKAYY HLLEQVAPKG DEEGVPAVVI DMSGLREKDD IQRAECMLQQ AERLGCRQFV TATDVVRGNP KLNLAFIANL FNRYPALHKP ENQDIDWGAL EGETREERTF RNWMNSLGVN PRVNHLYSDL SDALVIFQLY EKIKVPVDWN RVNKPPYPKL GGNMKKLENC NYAVELGKNQ AKFSLVGIGG QDLNEGNRTL TLALIWQLMR RYTLNILEEI GGGQKVNDDI IVNWVNETLR EAKKSSSISS FKDPKISTSL PVLDLIDAIQ PGSINYDLLK TENLNDDEKL NNAKYAISMA RKIGARVYAL PEDLVEVNPK MVMTVFACLM GKGMKRV
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