About Plastin-3
Plastin-3 (PLS3) is a protein
from Homo sapiens identified by UniProt accession
P13797, 630 residues long.
MolForge cross-references it against 0 known binders and
223 disease associations.
Target properties
| Protein name | Plastin-3 |
|---|
| UniProt accession | P13797 |
|---|
| Gene | PLS3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 630 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (223)
Diseases linked to this target (Open Targets).
- X-linked osteoporosis with fractures · score 0.61
- postmenopausal osteoporosis · score 0.45
- congenital diaphragmatic hernia · score 0.43
- osteoporosis · score 0.39
- genetic disorder · score 0.19
- osteogenesis imperfecta · score 0.18
- Osteoporosis · score 0.09
- Kallmann syndrome · score 0.07
- melorheostosis · score 0.07
- familial avascular necrosis of femoral head · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13797-F1 | alphafold | PREDICTED | 88.76 | — |
Amino-acid sequence (630 residues)
MDEMATTQIS KDELDELKEA FAKVDLNSNG FICDYELHEL FKEANMPLPG YKVREIIQKL MLDGDRNKDG KISFDEFVYI FQEVKSSDIA KTFRKAINRK EGICALGGTS ELSSEGTQHS YSEEEKYAFV NWINKALEND PDCRHVIPMN PNTDDLFKAV GDGIVLCKMI NLSVPDTIDE RAINKKKLTP FIIQENLNLA LNSASAIGCH VVNIGAEDLR AGKPHLVLGL LWQIIKIGLF ADIELSRNEA LAALLRDGET LEELMKLSPE ELLLRWANFH LENSGWQKIN NFSADIKDSK AYFHLLNQIA PKGQKEGEPR IDINMSGFNE TDDLKRAESM LQQADKLGCR QFVTPADVVS GNPKLNLAFV ANLFNKYPAL TKPENQDIDW TLLEGETREE RTFRNWMNSL GVNPHVNHLY ADLQDALVIL QLYERIKVPV DWSKVNKPPY PKLGANMKKL ENCNYAVELG KHPAKFSLVG IGGQDLNDGN QTLTLALVWQ LMRRYTLNVL EDLGDGQKAN DDIIVNWVNR TLSEAGKSTS IQSFKDKTIS SSLAVVDLID AIQPGCINYD LVKSGNLTED DKHNNAKYAV SMARRIGARV YALPEDLVEV KPKMVMTVFA CLMGRGMKRV
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