About Electron transfer flavoprotein subunit alpha, mitochondrial
Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) is a protein
from Homo sapiens identified by UniProt accession
P13804, 333 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Electron transfer flavoprotein subunit alpha, mitochondrial |
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| UniProt accession | P13804 |
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| Gene | ETFA |
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| Organism | Homo sapiens |
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| Length | 333 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- multiple acyl-CoA dehydrogenase deficiency · score 0.82
- Elevated circulating glutaric acid concentration · score 0.69
- Glutaric aciduria · score 0.57
- genetic disorder · score 0.41
- multiple acyl-CoA dehydrogenase deficiency, severe neonatal type · score 0.37
- multiple acyl-CoA dehydrogenase deficiency, mild type · score 0.37
- blood protein measurement · score 0.33
- central nervous system cancer · score 0.33
- traffic air pollution measurement · score 0.27
- glioma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13804-F1 | alphafold | PREDICTED | 94.15 | — |
Amino-acid sequence (333 residues)
MFRAAAPGQL RRAASLLRFQ STLVIAEHAN DSLAPITLNT ITAATRLGGE VSCLVAGTKC DKVAQDLCKV AGIAKVLVAQ HDVYKGLLPE ELTPLILATQ KQFNYTHICA GASAFGKNLL PRVAAKLEVA PISDIIAIKS PDTFVRTIYA GNALCTVKCD EKVKVFSVRG TSFDAAATSG GSASSEKASS TSPVEISEWL DQKLTKSDRP ELTGAKVVVS GGRGLKSGEN FKLLYDLADQ LHAAVGASRA AVDAGFVPND MQVGQTGKIV APELYIAVGI SGAIQHLAGM KDSKTIVAIN KDPEAPIFQV ADYGIVADLF KVVPEMTEIL KKK
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