About Glycogen [starch] synthase, muscle
Glycogen [starch] synthase, muscle (GYS1) is a protein
from Homo sapiens identified by UniProt accession
P13807, 737 residues long.
MolForge cross-references it against 0 known binders and
144 disease associations.
Target properties
| Protein name | Glycogen [starch] synthase, muscle |
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| UniProt accession | P13807 |
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| Gene | GYS1 |
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| Organism | Homo sapiens |
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| Length | 737 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (144)
Diseases linked to this target (Open Targets).
- glycogen storage disease due to muscle and heart glycogen synthase deficiency · score 0.78
- disorder of glycogen metabolism · score 0.53
- neurodegenerative disease · score 0.44
- Glycogen storage disease due to glycogenin deficiency · score 0.37
- endometrial cancer · score 0.21
- genetic disorder · score 0.19
- monocyte count · score 0.17
- head and neck squamous cell carcinoma · score 0.13
- blood protein measurement · score 0.10
- platelet count · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13807-F1 | alphafold | PREDICTED | 84.39 | — |
Amino-acid sequence (737 residues)
MPLNRTLSMS SLPGLEDWED EFDLENAVLF EVAWEVANKV GGIYTVLQTK AKVTGDEWGD NYFLVGPYTE QGVRTQVELL EAPTPALKRT LDSMNSKGCK VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH EWLAGVGLCL CRARRLPVAT IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC HLGVFPSYYE PWGYTPAECT VMGIPSISTN LSGFGCFMEE HIADPSAYGI YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY LGRYYMSARH MALSKAFPEH FTYEPNEADA AQGYRYPRPA SVPPSPSLSR HSSPHQSEDE EDPRNGPLEE DGERYDEDEE AAKDRRNIRA PEWPRRASCT SSTSGSKRNS VDTATSSSLS TPSEPLSPTS SLGEERN
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