About cAMP-dependent protein kinase type II-alpha regulatory subunit
cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A) is a protein
from Homo sapiens identified by UniProt accession
P13861, 404 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | cAMP-dependent protein kinase type II-alpha regulatory subunit |
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| UniProt accession | P13861 |
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| Gene | PRKAR2A |
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| Organism | Homo sapiens |
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| Length | 404 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- thyroid gland adenocarcinoma · score 0.28
- neuroinflammatory disorder · score 0.27
- lung adenocarcinoma · score 0.19
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- BMI-adjusted hip circumference · score 0.17
- esophageal cancer · score 0.15
- chronotype measurement · score 0.14
- Immature Reticulocyte Fraction Measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13861-F1 | alphafold | PREDICTED | 83.07 | — |
Amino-acid sequence (404 residues)
MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QGEKADSFYI IESGEVSILI RSRTKSNKDG GNQEVEIARC HKGQYFGELA LVTNKPRAAS AYAVGDVKCL VMDVQAFERL LGPCMDIMKR NISHYEEQLV KMFGSSVDLG NLGQ
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