About Sodium/glucose cotransporter 1
Sodium/glucose cotransporter 1 (SLC5A1) is a protein
from Homo sapiens identified by UniProt accession
P13866, 664 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Sodium/glucose cotransporter 1 |
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| UniProt accession | P13866 |
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| Gene | SLC5A1 |
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| Organism | Homo sapiens |
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| Length | 664 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (247)
Diseases linked to this target (Open Targets).
- glucose-galactose malabsorption · score 0.82
- type 2 diabetes mellitus · score 0.58
- type 1 diabetes mellitus · score 0.49
- heart failure · score 0.47
- diabetes mellitus · score 0.41
- chronic kidney disease · score 0.37
- Glucose intolerance · score 0.37
- nasopharyngeal neoplasm · score 0.37
- HbA1c measurement · score 0.28
- hypertrophic cardiomyopathy · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13866-F1 | alphafold | PREDICTED | 84.39 | — |
Amino-acid sequence (664 residues)
MDSSTWSPKT TAVTRPVETH ELIRNAADIS IIVIYFVVVM AVGLWAMFST NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAASGIAIGG FEWNALVLVV VLGWLFVPIY IKAGVVTMPE YLRKRFGGQR IQVYLSLLSL LLYIFTKISA DIFSGAIFIN LALGLNLYLA IFLLLAITAL YTITGGLAAV IYTDTLQTVI MLVGSLILTG FAFHEVGGYD AFMEKYMKAI PTIVSDGNTT FQEKCYTPRA DSFHIFRDPL TGDLPWPGFI FGMSILTLWY WCTDQVIVQR CLSAKNMSHV KGGCILCGYL KLMPMFIMVM PGMISRILYT EKIACVVPSE CEKYCGTKVG CTNIAYPTLV VELMPNGLRG LMLSVMLASL MSSLTSIFNS ASTLFTMDIY AKVRKRASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG QLFDYIQSIT SYLGPPIAAV FLLAIFWKRV NEPGAFWGLI LGLLIGISRM ITEFAYGTGS CMEPSNCPTI ICGVHYLYFA IILFAISFIT IVVISLLTKP IPDVHLYRLC WSLRNSKEER IDLDAEEENI QEGPKETIEI ETQVPEKKKG IFRRAYDLFC GLEQHGAPKM TEEEEKAMKM KMTDTSEKPL WRTVLNVNGI ILVTVAVFCH AYFA
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