Beta-enolase (ENO3)

About Beta-enolase

Beta-enolase (ENO3) is a protein from Homo sapiens identified by UniProt accession P13929, 434 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Beta-enolase
UniProt accession	P13929
Gene	ENO3
Organism	Homo sapiens
Length	434 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

glycogen storage disease due to muscle beta-enolase deficiency · score 0.72
disorder of glycogen metabolism · score 0.49
neurodegenerative disease · score 0.48
Red cell distribution width · score 0.20
mean platelet volume · score 0.20
platelet count · score 0.20
genetic disorder · score 0.19
amyotrophic lateral sclerosis · score 0.15
type 2 diabetes mellitus · score 0.11
intraocular pressure measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13929-F1	alphafold	PREDICTED	97.56	—

Amino-acid sequence (434 residues)

MAMQKIFARE ILDSRGNPTV EVDLHTAKGR FRAAVPSGAS TGIYEALELR DGDKGRYLGK GVLKAVENIN NTLGPALLQK KLSVVDQEKV DKFMIELDGT ENKSKFGANA ILGVSLAVCK AGAAEKGVPL YRHIADLAGN PDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGASSFKE AMRIGAEVYH HLKGVIKAKY GKDATNVGDE GGFAPNILEN NEALELLKTA IQAAGYPDKV VIGMDVAASE FYRNGKYDLD FKSPDDPARH ITGEKLGELY KSFIKNYPVV SIEDPFDQDD WATWTSFLSG VNIQIVGDDL TVTNPKRIAQ AVEKKACNCL LLKVNQIGSV TESIQACKLA QSNGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEALGDK AIFAGRKFRN PKAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards