General transcription factor IIF subunit 2 (GTF2F2)

About General transcription factor IIF subunit 2

General transcription factor IIF subunit 2 (GTF2F2) is a protein from Homo sapiens identified by UniProt accession P13984, 249 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	General transcription factor IIF subunit 2
UniProt accession	P13984
Gene	GTF2F2
Organism	Homo sapiens
Length	249 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
neurodegenerative disease · score 0.50
acrocephalosyndactyly · score 0.37
influenza · score 0.37
thyroid gland adenocarcinoma · score 0.28
endometrial cancer · score 0.27
clear cell renal carcinoma · score 0.27
head and neck squamous cell carcinoma · score 0.25
cutaneous melanoma · score 0.22
Red cell distribution width · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13984-F1	alphafold	PREDICTED	82.70	—

Amino-acid sequence (249 residues)

MAERGELDLT GAKQNTGVWL VKVPKYLSQQ WAKASGRGEV GKLRIAKTQG RTEVSFTLNE DLANIHDIGG KPASVSAPRE HPFVLQSVGG QTLTVFTESS SDKLSLEGIV VQRAECRPAA SENYMRLKRL QIEESSKPVR LSQQLDKVVT TNYKPVANHQ YNIEYERKKK EDGKRARADK QHVLDMLFSA FEKHQYYNLK DLVDITKQPV VYLKEILKEI GVQNVKGIHK NTWELKPEYR HYQGEEKSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards