About Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) is a protein
from Homo sapiens identified by UniProt accession
P13995, 350 residues long.
MolForge cross-references it against 0 known binders and
227 disease associations.
Target properties
| Protein name | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
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| UniProt accession | P13995 |
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| Gene | MTHFD2 |
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| Organism | Homo sapiens |
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| Length | 350 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (227)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- mean platelet volume · score 0.35
- cancer · score 0.11
- acute myeloid leukemia · score 0.10
- neoplasm · score 0.10
- lung adenocarcinoma · score 0.10
- non-small cell lung carcinoma · score 0.10
- breast cancer · score 0.09
- triple-negative breast cancer · score 0.08
- bladder transitional cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P13995-F1 | alphafold | PREDICTED | 89.62 | — |
Amino-acid sequence (350 residues)
MAATSLMSAL AARLLQPAHS CSLRLRPFHL AAVRNEAVVI SGRKLAQQIK QEVRQEVEEW VASGNKRPHL SVILVGENPA SHSYVLNKTR AAAVVGINSE TIMKPASISE EELLNLINKL NNDDNVDGLL VQLPLPEHID ERRICNAVSP DKDVDGFHVI NVGRMCLDQY SMLPATPWGV WEIIKRTGIP TLGKNVVVAG RSKNVGMPIA MLLHTDGAHE RPGGDATVTI SHRYTPKEQL KKHTILADIV ISAAGIPNLI TADMIKEGAA VIDVGINRVH DPVTAKPKLV GDVDFEGVRQ KAGYITPVPG GVGPMTVAML MKNTIIAAKK VLRLEEREVL KSKELGVATN
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