About 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) is a protein
from Homo sapiens identified by UniProt accession
P14060, 373 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
|---|
| UniProt accession | P14060 |
|---|
| Gene | HSD3B1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 373 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (112)
Diseases linked to this target (Open Targets).
- 17-hydroxyprogesterone measurement · score 0.27
- ovarian cancer · score 0.18
- squamous cell lung carcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.11
- cutaneous melanoma · score 0.11
- metabolite measurement · score 0.07
- Crohn's disease · score 0.05
- pancreatic adenocarcinoma · score 0.04
- hyperinsulinemic hypoglycemia, familial, 4 · score 0.04
- psoriasis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14060-F1 | alphafold | PREDICTED | 94.17 | — |
Amino-acid sequence (373 residues)
MTGWSCLVTG AGGFLGQRII RLLVKEKELK EIRVLDKAFG PELREEFSKL QNKTKLTVLE GDILDEPFLK RACQDVSVII HTACIIDVFG VTHRESIMNV NVKGTQLLLE ACVQASVPVF IYTSSIEVAG PNSYKEIIQN GHEEEPLENT WPAPYPHSKK LAEKAVLAAN GWNLKNGGTL YTCALRPMYI YGEGSRFLSA SINEALNNNG ILSSVGKFST VNPVYVGNVA WAHILALRAL QDPKKAPSIR GQFYYISDDT PHQSYDNLNY TLSKEFGLRL DSRWSFPLSL MYWIGFLLEI VSFLLRPIYT YRPPFNRHIV TLSNSVFTFS YKKAQRDLAY KPLYSWEEAK QKTVEWVGSL VDRHKETLKS KTQ
Explore 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets