Cathepsin E (CTSE)

About Cathepsin E

Cathepsin E (CTSE) is a protein from Homo sapiens identified by UniProt accession P14091, 396 residues long. MolForge cross-references it against 0 known binders and 215 disease associations.

Target properties

Protein name	Cathepsin E
UniProt accession	P14091
Gene	CTSE
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (215)

Diseases linked to this target (Open Targets).

prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11
prostate cancer · score 0.11
Barrett's esophagus · score 0.10
esophageal adenocarcinoma · score 0.07
graft versus host disease · score 0.05
bladder transitional cell carcinoma · score 0.05
sweet syndrome · score 0.05
neoplasm · score 0.05
hypotrichosis simplex of the scalp · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14091-F1	alphafold	PREDICTED	87.15	—

Amino-acid sequence (396 residues)

MKTLLLLLLV LLELGEAQGS LHRVPLRRHP SLKKKLRARS QLSEFWKSHN LDMIQFTESC SMDQSAKEPL INYLDMEYFG TISIGSPPQN FTVIFDTGSS NLWVPSVYCT SPACKTHSRF QPSQSSTYSQ PGQSFSIQYG TGSLSGIIGA DQVSVEGLTV VGQQFGESVT EPGQTFVDAE FDGILGLGYP SLAVGGVTPV FDNMMAQNLV DLPMFSVYMS SNPEGGAGSE LIFGGYDHSH FSGSLNWVPV TKQAYWQIAL DNIQVGGTVM FCSEGCQAIV DTGTSLITGP SDKIKQLQNA IGAAPVDGEY AVECANLNVM PDVTFTINGV PYTLSPTAYT LLDFVDGMQF CSSGFQGLDI HPPAGPLWIL GDVFIRQFYS VFDRGNNRVG LAPAVP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards