Glial fibrillary acidic protein (GFAP)

About Glial fibrillary acidic protein

Glial fibrillary acidic protein (GFAP) is a protein from Homo sapiens identified by UniProt accession P14136, 432 residues long. MolForge cross-references it against 0 known binders and 1,065 disease associations.

Target properties

Protein name	Glial fibrillary acidic protein
UniProt accession	P14136
Gene	GFAP
Organism	Homo sapiens
Length	432 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1065)

Diseases linked to this target (Open Targets).

Alexander disease · score 0.87
genetic disorder · score 0.41
Seizure · score 0.40
Alexander disease type I · score 0.37
Alexander disease type II · score 0.37
Progressive ventriculomegaly · score 0.27
scoliosis · score 0.26
primary ciliary dyskinesia · score 0.19
lung adenocarcinoma · score 0.19
cutaneous melanoma · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14136-F1	alphafold	PREDICTED	79.99	—

Amino-acid sequence (432 residues)

MERRRITSAA RRSYVSSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV DFSLAGALNA GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL RELRLRLDQL TANSARLEVE RDNLAQDLAT VRQKLQDETN LRLEAENNLA AYRQEADEAT LARLDLERKI ESLEEEIRFL RKIHEEEVRE LQEQLARQQV HVELDVAKPD LTAALKEIRT QYEAMASSNM HEAEEWYRSK FADLTDAAAR NAELLRQAKH EANDYRRQLQ SLTCDLESLR GTNESLERQM REQEERHVRE AASYQEALAR LEEEGQSLKD EMARHLQEYQ DLLNVKLALD IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNIVV KTVEMRDGEV IKESKQEHKD VM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards