About Endothelin-3
Endothelin-3 (EDN3) is a protein
from Homo sapiens identified by UniProt accession
P14138, 238 residues long.
MolForge cross-references it against 0 known binders and
237 disease associations.
Target properties
| Protein name | Endothelin-3 |
|---|
| UniProt accession | P14138 |
|---|
| Gene | EDN3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 238 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (237)
Diseases linked to this target (Open Targets).
- Waardenburg-Shah syndrome · score 0.67
- Hirschsprung disease · score 0.56
- Waardenburg syndrome · score 0.51
- platelet count · score 0.40
- platelet component distribution width · score 0.38
- central hypoventilation syndrome, congenital · score 0.37
- hair color · score 0.30
- Aganglionic megacolon · score 0.29
- sensorineural hearing loss · score 0.27
- Sensorineural hearing impairment · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14138-F1 | alphafold | PREDICTED | 55.89 | — |
Amino-acid sequence (238 residues)
MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS SNSRTAEKTD KEEEGKVEVK DQQSKQALDL HHPKLMPGSG LALAPSTCPR CLFQEGAP
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