L-selectin (SELL)

About L-selectin

L-selectin (SELL) is a protein from Homo sapiens identified by UniProt accession P14151, 372 residues long. MolForge cross-references it against 0 known binders and 730 disease associations.

Target properties

Protein name	L-selectin
UniProt accession	P14151
Gene	SELL
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (730)

Diseases linked to this target (Open Targets).

monocyte count · score 0.42
blood protein measurement · score 0.41
eosinophil count · score 0.39
leukocyte count · score 0.38
eosinophil percentage of leukocytes · score 0.36
L-Selectin measurement · score 0.33
total blood protein measurement · score 0.31
monocyte percentage of leukocytes · score 0.31
sickle cell anemia · score 0.27
alkaline phosphatase measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14151-F1	alphafold	PREDICTED	85.32	—

Amino-acid sequence (372 residues)

MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW QRARRFCRDN YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW VGTNKSLTEE AENWGDGEPN NKKNKEDCVE IYIKRNKDAG KWNDDACHKL KAALCYTASC QPWSCSGHGE CVEIINNYTC NCDVGYYGPQ CQFVIQCEPL EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT CGPFGNWSSP EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF IIWLARRLKK GKKSKRSMND PY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards