Perforin-1 (PRF1)

About Perforin-1

Perforin-1 (PRF1) is a protein from Homo sapiens identified by UniProt accession P14222, 555 residues long. MolForge cross-references it against 0 known binders and 939 disease associations.

Target properties

Protein name	Perforin-1
UniProt accession	P14222
Gene	PRF1
Organism	Homo sapiens
Length	555 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (939)

Diseases linked to this target (Open Targets).

Familial hemophagocytic lymphohistiocytosis · score 0.83
Aplastic anemia · score 0.65
lymphoma · score 0.63
autoinflammatory syndrome · score 0.52
genetic disorder · score 0.52
lymphocyte count · score 0.47
lymphocyte percentage of leukocytes · score 0.42
type 1 diabetes mellitus · score 0.40
neutrophil percentage of leukocytes · score 0.39
aplastic anemia · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14222-F1	alphafold	PREDICTED	90.71	—

Amino-acid sequence (555 residues)

MAARLLLLGI LLLLLPLPVP APCHTAARSE CKRSHKFVPG AWLAGEGVDV TSLRRSGSFP VDTQRFLRPD GTCTLCENAL QEGTLQRLPL ALTNWRAQGS GCQRHVTRAK VSSTEAVARD AARSIRNDWK VGLDVTPKPT SNVHVSVAGS HSQAANFAAQ KTHQDQYSFS TDTVECRFYS FHVVHTPPLH PDFKRALGDL PHHFNASTQP AYLRLISNYG THFIRAVELG GRISALTALR TCELALEGLT DNEVEDCLTV EAQVNIGIHG SISAEAKACE EKKKKHKMTA SFHQTYRERH SEVVGGHHTS INDLLFGIQA GPEQYSAWVN SLPGSPGLVD YTLEPLHVLL DSQDPRREAL RRALSQYLTD RARWRDCSRP CPPGRQKSPR DPCQCVCHGS AVTTQDCCPR QRGLAQLEVT FIQAWGLWGD WFTATDAYVK LFFGGQELRT STVWDNNNPI WSVRLDFGDV LLATGGPLRL QVWDQDSGRD DDLLGTCDQA PKSGSHEVRC NLNHGHLKFR YHARCLPHLG GGTCLDYVPQ MLLGEPPGNR SGAVW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards