About Glucosidase 2 subunit beta
Glucosidase 2 subunit beta (PRKCSH) is a protein
from Homo sapiens identified by UniProt accession
P14314, 528 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Glucosidase 2 subunit beta |
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| UniProt accession | P14314 |
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| Gene | PRKCSH |
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| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- polycystic liver disease 1 · score 0.75
- Isolated polycystic liver disease · score 0.64
- autosomal dominant polycystic liver disease · score 0.51
- liver disease · score 0.50
- COVID-19 · score 0.37
- Genetic visceral malformation of the liver, biliary tract, pancreas or spleen · score 0.37
- severe acute respiratory syndrome · score 0.37
- serum metabolite measurement · score 0.26
- genetic disorder · score 0.19
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14314-F1 | alphafold | PREDICTED | 84.13 | — |
Amino-acid sequence (528 residues)
MLLPLLLLLP MCWAVEVKRP RGVSLTNHHF YDESKPFTCL DGSATIPFDQ VNDDYCDCKD GSDEPGTAAC PNGSFHCTNT GYKPLYIPSN RVNDGVCDCC DGTDEYNSGV ICENTCKEKG RKERESLQQM AEVTREGFRL KKILIEDWKK AREEKQKKLI ELQAGKKSLE DQVEMLRTVK EEAEKPEREA KEQHQKLWEE QLAAAKAQQE QELAADAFKE LDDDMDGTVS VTELQTHPEL DTDGDGALSE AEAQALLSGD TQTDATSFYD RVWAAIRDKY RSEALPTDLP APSAPDLTEP KEEQPPVPSS PTEEEEEEEE EEEEEAEEEE EEEDSEEAPP PLSPPQPASP AEEDKMPPYD EQTQAFIDAA QEARNKFEEA ERSLKDMEES IRNLEQEISF DFGPNGEFAY LYSQCYELTT NEYVYRLCPF KLVSQKPKLG GSPTSLGTWG SWIGPDHDKF SAMKYEQGTG CWQGPNRSTT VRLLCGKETM VTSTTEPSRC EYLMELMTPA ACPEPPPEAP TEDDHDEL
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