Interferon regulatory factor 2 (IRF2)

About Interferon regulatory factor 2

Interferon regulatory factor 2 (IRF2) is a protein from Homo sapiens identified by UniProt accession P14316, 349 residues long. MolForge cross-references it against 0 known binders and 261 disease associations.

Target properties

Protein name	Interferon regulatory factor 2
UniProt accession	P14316
Gene	IRF2
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (261)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
lysosomal storage disease · score 0.27
Parkinson disease · score 0.27
Alzheimer disease · score 0.27
multiple sclerosis · score 0.27
Antithrombotic agent use measurement · score 0.24
sex hormone-binding globulin measurement · score 0.22
type 1 diabetes mellitus · score 0.21
chronic lymphocytic leukemia · score 0.19
physical activity measurement · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14316-F1	alphafold	PREDICTED	63.94	—

Amino-acid sequence (349 residues)

MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMH AARHGWDVEK DAPLFRNWAI HTGKHQPGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIK KGNNAFRVYR MLPLSERPSK KGKKPKTEKE DKVKHIKQEP VESSLGLSNG VSDLSPEYAV LTSTIKNEVD STVNIIVVGQ SHLDSNIENQ EIVTNPPDIC QVVEVTTESD EQPVSMSELY PLQISPVSSY AESETTDSVP SDEESAEGRP HWRKRNIEGK QYLSNMGTRG SYLLPGMASF VTSNKPDLQV TIKEESNPVP YNSSWPPFQD LPLSSSMTPA SSSSRPDRET RASVIKKTSD ITQARVKSC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards